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- Title
Effect of Terminalia catappa on lipid profile in transplanted fibrosarcoma in rats.
- Authors
Naitik, Pandya; Prakash, Tigari; Kotresha, Dupadahalli; Rao, Nadendla Rama
- Abstract
To evaluate the effect of an antitumor activity of Terminalia catappa on lipid lowering activity in transplanted fibrosarcoma in Wistar albino rats. Methylcholantherene-induced fibrosarcoma was transplanted in rats. After 30th day when tumor became palpable, started the treatment of ethanolic extract of Terminalia catappa by orally (250 and 500 mg/kg) for a period of 20 days. The blood sample was collected on 21st day, and the liver and the kidney were also removed for studying the lipid profile in serum and the tissues. The levels of total cholesterol, triglycerides and very low density lipoprotein (VLDL) were markedly elevated and high density lipoprotein (HDL) was markedly decreased in the serum of tumor bearing rats. Significant alterations were also observed in the lipid profile of liver and kidney. These changes were significantly reversed in Terminalia catappa (500 mg/kg) treated animals. The reversal of altered lipid levels to normal values in rats with experimentally induced tumor was showed antitumor activity by Terminalia catappa.
- Subjects
HIGH density lipoproteins; BLOOD lipoproteins; FIBROSARCOMA; RATS; MURIDAE
- Publication
Indian Journal of Pharmacology, 2012, Vol 44, Issue 3, p390
- ISSN
0253-7613
- Publication type
Article
- DOI
10.4103/0253-7613.96345