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- Title
The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus.
- Authors
Hedestam, Gunilla B. Karlsson; Fouchier, Ron A. M.; Phogat, Sanjay; Burton, Dennis R.; Sodroski, Joseph; Wyatt, Richard T.
- Abstract
The ability to elicit broadly neutralizing antibody responses against HIV-1 is a crucial goal for a prophylactic HIV-1 vaccine. Here, we discuss the difficulties of achieving broad HIV-1 neutralization in the context of both the effective annual human influenza virus vaccine and the need to develop a pandemic influenza vaccine. Immunogen-design strategies are underway to target functionally conserved regions of the HIV-1 envelope glycoproteins, and similar strategies might be applicable to pandemic influenza virus vaccine development. Efforts to develop broadly neutralizing vaccines against either HIV-1 or influenza virus might establish a paradigm for future vaccines against highly variable pathogens.
- Subjects
VACCINATION; ORTHOMYXOVIRUSES; PATHOGENIC microorganisms; RESPIRATORY infections; HIV; INFLUENZA prevention
- Publication
Nature Reviews Microbiology, 2008, Vol 6, Issue 2, p143
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro1819