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- Title
Targeting the endothelium by combining endothelin-1 antagonism and SGLT-2 inhibition: better together?
- Authors
Ambery, Phil; Greasley, Peter J.; Menzies, Robert I.; Brynne, Lena; Kulkarni, Spoorthy; Oscarsson, Jan; Davenport, Anthony P.
- Abstract
Endothelin A and B receptors, together with sodium-glucose cotransporter-2 (SGLT-2) channels are important targets in improving endothelial function and intervention with inhibitors has been the subject of multiple mechanistic and clinical outcome trials over recent years. Notable successes include the treatment of pulmonary hypertension with endothelin receptor antagonists, and the treatment of heart failure and chronic kidney disease with SGLT-2 inhibitors.With distinct and complementary mechanisms, in this review, we explore the logic of combination therapy for a number of diseases which have endothelial dysfunction at their heart.
- Subjects
PREPROENDOTHELIN; CHRONIC kidney failure; TREATMENT effectiveness; ENDOTHELIN receptors; ENDOTHELIUM diseases; ALDOSTERONE antagonists
- Publication
Clinical Science, 2024, Vol 138, Issue 11, p687
- ISSN
0143-5221
- Publication type
Article
- DOI
10.1042/CS20240605