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- Title
Breaking up with a kinky SUMO.
- Authors
Huang, Danny T.; Schulman, Brenda A.
- Abstract
The article presents the structural studies of small ubiquitin-like modifier (SUMO)-specific protease-substrate complexes which provide new insight into hydrolysis of the peptide bond at the C terminus of SUMO. The structures and associated biophysical and kinetic analyses also provide insight into ubiquitin-like proteins preferences for distinct SUMO isoforms. They have also presented the comparison of the catalytic features of SUMO proteases and deubiquitinating enzymes.
- Subjects
UBIQUITIN; PROTEINS; PROTEOLYTIC enzymes; HYDROLASES; HYDROLYSIS; PEPTIDES
- Publication
Nature Structural & Molecular Biology, 2006, Vol 13, Issue 12, p1045
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb1206-1045