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- Title
Enantioselective Copper-Catalyzed Intramolecular N−H Bond Insertion: Synthesis of Chiral 2-Carboxytetrahydroquinolines.
- Authors
Song, Xiao ‐ Guang; Ren, Yuan ‐ Yuan; Zhu, Shou ‐ Fei; Zhou, Qi ‐ Lin
- Abstract
The first highly enantioselective intramolecular N−H bond insertion was realized by using copper catalysts modified with chiral spirobisoxazoline ligands, which provides a novel strategy for the synthesis of chiral 2-carboxytetrahydroquinolines. This reaction features fast reaction rate, high yield, high enantioselectivity, and mild reaction conditions.
- Subjects
ASYMMETRIC synthesis; CARBENES; CARBOXYLASES; QUINOLINE; COPPER
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 15, p2366
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201600390