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- Title
The effects of cashew gum as anti-hypertensive agent.
- Authors
Carestiato, Tatiana; Aguila, Marcia B.; Mothé, Cheila G.
- Abstract
The effects of cashew gum over heart samples of spontaneously hypertensive rats (SHR) were studied by Thermal Analysis and Micrographs. During the experiment, ten rats received daily by gavage 500 mg/kg of cashew gum (CG groups) and the other ten rats received only fresh water (Control groups). After 17 weeks of experiment, blood pressure in CG groups was approximately 8% lower and after 24 weeks it was 20% lower than Control groups. At seven months of experiment ten rats (five of each group: Control 7 and CG 7) and at nine months of experiment the other rats (Control 9 and CG 9) were sacrificed. Pieces of left ventricle were studied by thermogravimetry (TG), differential thermal analysis (DTA) and microscopy. The myocardial appearance of CG groups showed the presence of greater number of cardiomyocytes and more capillaries among the cells. The myocardium of Control groups showed more areas with diffuse interstitial fibrosis and hypertrophied cardiomyocytes. TG curves depict two steps for all samples. CG 7 and CG 9 presented the least amount of residues (6.0 ± 0.5) in the heart. DTA curves depict two endothermic events (Tpeak1: 85 °C; Tpeak2: 298 °C). The results suggest that cashew gum contributes to improve cardiovascular health of SHR and to postpone the aging process of their hearts.
- Subjects
HYPERTENSION; LABORATORY mice; CASHEW tree; THERMOGRAVIMETRY; MICROCIRCULATION
- Publication
Journal of Thermal Analysis & Calorimetry, 2009, Vol 97, Issue 2, p717
- ISSN
1388-6150
- Publication type
Article
- DOI
10.1007/s10973-009-0283-1