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- Title
Electronic circular dichroism for the detection of microalbuminuria.
- Authors
Habartová, Lucie; Logerová, Hana; Tomaník, Lukáš; Marešová, Aneta; Setnička, Vladimír
- Abstract
Abstract: Over the past decades, chiroptical spectroscopy has proved its incomparable ability to elucidate the structure and spatial arrangement of chiral molecules. Systematic analysis of biomolecules in the natural environment of biofluids, however, remains challenging. In this study, we used chiroptical spectroscopy to monitor urinary levels of human serum albumin. Not only severe proteinuria but even just a slightly increased urinary excretion of albumin (microalbuminuria) may indicate serious health complications, especially for diabetic individuals. Given the chiral nature of albumin and its typical spectral pattern, it may be easily observable by chiroptical spectroscopy, particularly electronic circular dichroism. The performed chiroptical analysis of urine not only allowed the detection of clinically confirmed microalbuminuria but was also able to reveal this pathological condition in cases beyond the diagnostic capability of common clinical procedures. Thus, our approach suggests that electronic circular dichroism is a useful tool for the fast and reliable qualitative monitoring of microalbuminuria with the potential for a quantitative analysis in the future.
- Subjects
CIRCULAR dichroism; ALBUMINURIA; PROTEINURIA diagnosis; SERUM albumin; SPECTROMETRY; DIAGNOSIS
- Publication
Chirality, 2018, Vol 30, Issue 5, p576
- ISSN
0899-0042
- Publication type
Article
- DOI
10.1002/chir.22832