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- Title
Admission free-fatty acid level is a predictor of the mid-term worsening renal function in patients with ST-segment elevation myocardial infarction.
- Authors
Gohbara, Masaomi; Iwahashi, Noriaki; Okada, Kozo; Minamimoto, Yugo; Matsuzawa, Yasushi; Konishi, Masaaki; Hibi, Kiyoshi; Kosuge, Masami; Ebina, Toshiaki; Sugano, Teruyasu; Ishikawa, Toshiyuki; Tamura, Kouichi; Kimura, Kazuo
- Abstract
Whether free fatty acids (FFAs), which are generators of reactive oxygen species and substrates of cytotoxic lipid peroxidation products in proximal tubules of the kidney, can be a predictor of worsening renal function (WRF) is not fully elucidated. A total of 110 patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention within 24 h after symptom onset were included. The exclusion criteria were out-of-hospital cardiac arrest, vasospastic angina, hemodialysis, and/or lack of data. FFAs and serum cystatin C were measured on admission, and urinary liver-type fatty acid-binding protein (L-FABP) was measured 3 h after admission. WRF, defined as an increase in serum creatinine by ≥ 0.3 mg/dL for 2-year follow-up, was observed in 16 patients (15%). A multivariate logistic regression analysis (a stepwise algorithm) revealed that the FFA level was an independent predictor of WRF (P = 0.024). The FFA level was associated with WRF adjusted after serum cystatin C (odds ratio [OR]: 1.378 per 1 mEq/L, P = 0.017), L-FABP (OR: 1.370 per 1 mEq/L, P = 0.016), or the Mehran contrast-induced nephropathy (CIN) risk score (OR: 1.362 per 1 mEq/L, P = 0.021). The FFA level was inversely associated with the change in estimated glomerular filtration rate level for 2 years (R2 = 0.051, P = 0.018). The FFA level on admission was associated with the mid-term WRF in patients with STEMI.
- Subjects
ST elevation myocardial infarction; MYOCARDIAL infarction; KIDNEY physiology; FATTY acid-binding proteins; PROXIMAL kidney tubules; FREE fatty acids
- Publication
Heart & Vessels, 2022, Vol 37, Issue 5, p720
- ISSN
0910-8327
- Publication type
Article
- DOI
10.1007/s00380-021-01982-0