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- Title
Nonenzymatic Oligomerization Reactions on Templates Containing Inosinic Acid or Diaminopurine Nucleotide Residues.
- Authors
Kozlov, Igor A.; Orgel, Leslie E.
- Abstract
The template-directed oligomerization of nucleoside-5′-phosphoro-2-methyl imidazolides on standard oligonucleotide templates has been studied extensively. Here, we describe experiments with templates in which inosinic acid (I) is substituted for guanylic acid, or 2,6-diaminopurine nucleotide (D) for adenylic acid. We find that the substitution of I for G in a template is strongly inhibitory and prevents any incorporation of C into internal positions in the oligomeric products of the reaction. The substitution of D for A, on the contrary, leads to increased incorporation of U into the products. We found no evidence for the template-directed facilitation of oligomerization of A or I through A - I base pairing. The significance of these results for prebiotic chemistry is discussed.
- Publication
Helvetica Chimica Acta, 1999, Vol 82, Issue 11, p1799
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/(SICI)1522-2675(19991110)82:11<1799::AID-HLCA1799>3.0.CO;2-S