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- Title
Ovarian metastases in young women with colorectal cancer: a retrospective multicenter cohort study.
- Authors
van der Meer, R.; Bakkers, C.; Wegdam, J. A.; Lettinga, T.; Boerma, E. G.; Aarts, F.; de Hingh, I. H. J. T.; Roumen, R. M. H.
- Abstract
Background and purpose: Previous studies indicated that approximately 3.4% of female colorectal cancer (CRC) patients are at increased risk of developing ovarian metastases (OM). It has been suggested that young women more frequently develop this form of metastatic disease. Methods: This study evaluated, in 6 Dutch hospitals, the proportion of young women with CRC who developed OM. Results: In a cohort of 200 young (age ≤ 55) women with CRC, the proportion of patients diagnosed with synchronous or metachronous OM was calculated. This study revealed that 5% (n = 10) of young female CRC patients developed ovarian metastases resulting in a 5-year overall survival rate of approximately 40%. Furthermore, six patients had concurrent peritoneal metastases, five patients had bilateral ovarian metastases, and five patients had synchronous metastases, while the median time of the occurrence of metachronous metastases (n = 5) was 19 months. Conclusion: This retrospective multicenter cohort study indicates that 5% of young women with CRC either present with or develop OM. This result appears to be clinically relevant and demonstrates the need for improved surveillance for young women diagnosed with CRC.
- Subjects
YOUNG women; COLORECTAL cancer; CANCER patients; COHORT analysis; METASTASIS
- Publication
International Journal of Colorectal Disease, 2022, Vol 37, Issue 8, p1865
- ISSN
0179-1958
- Publication type
Article
- DOI
10.1007/s00384-022-04217-4