We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Familial aggregation of delusional depression: re-examination in a recent family study.
- Authors
Goldstein, Risë B.; Horwath, Ewald; Wickramaratne, Priya J.; Wolk, Susan I.; Warner, Virginia; Weissman, Myrna M.; Goldstein, R B; Horwath, E; Wickramaratne, P J; Wolk, S I; Warner, V; Weissman, M M
- Abstract
<bold>Background: </bold>Delusional (D-MDD) and nondelusional depression (ND-MDD) differ in clinical presentation, biological abnormalities, course of illness, and treatment response. Family data, however, have been less consistent regarding differential risk both for any major depression (MDD) and specifically D-MDD in relatives of D-MDD probands. In an earlier family study, we observed a 1.5-fold increase in rates of any MDD, specificity of transmission of D-MDD, and increased rates of bipolar disorders in relatives of D-MDD compared to relatives of ND-MDD probands. In a new family study, we attempted to replicate these findings.<bold>Method: </bold>A family study of 361 directly interviewed adult first-degree relatives (FDRs) of 163 probands (118 with MDD and 45 screened normal controls) was used to examine familial aggregation of any MDD, D-MDD, and bipolarity by proband delusional status.<bold>Results: </bold>Compared to FDRs of ND-MDD probands, FDRs of D-MDD probands were at modestly increased risk for any MDD. These results were unaffected by adjustment for proband ascertainment source, comorbidity, or whether probands had chronologically primary MDD. There was a trend toward increased rates of broadly defined bipolarity (bipolar I, bipolar II, or cyclothymia) in FDRs of D-MDD compared to FDRs of ND-MDD probands.<bold>Conclusion: </bold>Results from the present study were broadly consistent with those from our previous work. While other lines of evidence for D-MDD as a distinct subtype are more compelling than family data, it would be of methodologic interest to identify sources of inconsistency across studies in findings concerning the familial aggregation of delusional depression.
- Subjects
MENTAL depression; DELUSIONS; COGNITION disorders; PATHOLOGICAL psychology; FAMILIES
- Publication
Depression & Anxiety (1091-4269), 1998, Vol 8, Issue 4, p160
- ISSN
1091-4269
- Publication type
journal article
- DOI
10.1002/(SICI)1520-6394(1998)8:4<160::AID-DA5>3.0.CO;2-A