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- Title
Genomic approaches to studying the human microbiota.
- Authors
Weinstock, George M.
- Abstract
The human body is colonized by a vast array of microbes, which form communities of bacteria, viruses and microbial eukaryotes that are specific to each anatomical environment. Every community must be studied as a whole because many organisms have never been cultured independently, and this poses formidable challenges. The advent of next-generation DNA sequencing has allowed more sophisticated analysis and sampling of these complex systems by culture-independent methods. These methods are revealing differences in community structure between anatomical sites, between individuals, and between healthy and diseased states, and are transforming our view of human biology.
- Subjects
BACTERIA; HUMAN microbiota; EUKARYOTES; NUCLEOTIDE sequence; MICROBIAL cultures; RIBOSOMAL RNA; HUMAN genes
- Publication
Nature, 2012, Vol 489, Issue 7415, p250
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature11553