We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synovial tumefactive extramedullary hematopoiesis associated to polycythemia vera.
- Authors
José Carrasco Juan; María García Castro; Manuel González Gaitano; Alfonso Bonilla Arjona
- Abstract
Abstract??The case of a 66-year-old male patient with a chronic myeloproliferative type polycythemia vera disorder, who after 2?years of evolution is developing a tumefactive extramedullary hematopoiesis (TEH) located in the synovial of the articulation in the right knee, is described. The tumor histologically consists of a relatively lax and edematous synovial structure diffusely infiltrated by mature and semimature hematopoietic cellular population. The simultaneous study of the bone marrow reveals medullar spaces full of hematopoietic cellularity, with a predominance of megakaryocytic and red series, and with the addition of severe reticulin fibrosis, facts that suggest a progression toward myelofibrosis. The TEH developed in tissues without a reticulum endothelial system is very uncommon. We provide data about the first case located in the synovial membrane and we review the literature regarding this pathologic entity.
- Subjects
POLYCYTHEMIA; HEMATOPOIESIS; BONE marrow; SYNOVIAL membranes
- Publication
Virchows Archiv: European Journal of Pathology, 2007, Vol 450, Issue 1, p109
- ISSN
0945-6317
- Publication type
Article