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- Title
Limited MHC class II gene polymorphism in the West African chimpanzee is distributed maximally by haplotype diversity.
- Authors
Otting, Nel; de Groot, Natasja G.; Bontrop, Ronald E.
- Abstract
Chimpanzees have been used for some time as an animal model in research on immune-related diseases in humans. The major histocompatibility complex (MHC) region of the chimpanzee has also been the subject of studies in which the attention was mainly on the class I genes. Although full-length sequence information is available on the DRB region genes, such detailed information is lacking for the other class II genes and, if present, is based mainly on exon 2 sequences. In the present study, full-length sequencing was performed on DQ, DP, and DRA genes in a cohort of 67 pedigreed animals, thereby allowing a thorough analysis of the MHC class II repertoire. The results demonstrate that the number of MHC class II lineages and alleles is relatively low, whereas haplotype diversity (combination of genes/alleles on a chromosome) seems to have been maximised by crossing-over processes.
- Subjects
MAJOR histocompatibility complex; GENETIC polymorphisms; CHIMPANZEES physiology; HAPLOTYPES; IMMUNE response; EXONS (Genetics)
- Publication
Immunogenetics, 2019, Vol 71, Issue 1, p13
- ISSN
0093-7711
- Publication type
Article
- DOI
10.1007/s00251-018-1080-4