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- Title
Effect of Long-Term Prazosin and Yohimbine Administration on c-Fos Expression in Spinal Neurons: Inhibitory Effect of Alpha-1 and Alpha-2 Adrenoceptors on Afferents from the Lower Urinary Tract.
- Authors
Haga, Nobuhiro; Aikawa, Ken; Shishido, Keiichi; Yanagida, Tomohiko; Kushida, Nobuhiro; Takahashi, Norio; Yazaki, Junji; Yamaguchi, Osamu
- Abstract
Introduction: To investigate the effects of long-term administration of the α1-adrenoceptor antagonist prazosin and the α2-adrenoceptor antagonist yohimbine on afferent inputs from the lower urinary tract by evaluating c-Fos expression in the spinal cord. Materials and Methods: Prazosin or yohimbine was administered for 4 weeks in rats using an osmotic pump. Effects of these agents on urodynamic parameters were determined by continuous cystometry in conscious rats. After cystometry, c-Fos expression in the dorsal horn of the L6 spinal cord was measured by immunohistochemistry. Results: The administration of prazosin (0.12 mg/kg/day) or yohimbine (0.10 mg/kg/day) significantly increased micturition interval and bladder capacity, but did not affect micturition pressure and residual urine volume. The numbers of c-Fos-positive neurons in the dorsal horn were significantly lower in rats that received prazosin than in controls. Yohimbine reduced the number of c-Fos-positive neurons in part of the dorsal horn. Conclusions: Long-term administration of prazosin and yohimbine at clinically recommended doses can exert inhibitory effects on afferent pathways from the lower urinary tract during the storage phase. These reductions of the afferent input result in the increased bladder capacity and increased micturition interval. Copyright © 2011 S. Karger AG, Basel
- Subjects
SPINAL cord; GENE expression; PRAZOSIN; YOHIMBINE; DRUG side effects; ADRENERGIC receptors; CYSTOMETRY; LABORATORY rats
- Publication
Urologia Internationalis, 2011, Vol 87, Issue 2, p230
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000324274