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- Title
Secondary Acute Monocytic Leukemia Occurring during the Treatment of a Testicular Germ Cell Tumor.
- Authors
Nonomura, Norio; Murosaki, Nobukazu; Kojima, Yasuyuki; Kondoh, Nobuyuki; Seguchi, Toshinobu; Takeda, Yoshito; Oji, Yusuke; Ogawa, Hiroyasu; Sugiyama, Haruo; Miki, Tsuneharu; Okuyama, Äkïhïko
- Abstract
Secondary leukemia following chemotherapy or radiotherapy for mediastinal germ cell tumors is a well-described entity. It also may occur in patients with testicular germ cell tumors. We report a case of acute monocytic leukemia occurring in a 44-year-old man who received etoposide-based chemotherapy and radiotherapy for a recurrent, metastatic testicular germ cell tumor. The patient recevied 14 cycles of systemic chemotherapy for pulmonary and para-aortic lymph node metastases following his initial orchiectomy. The total amount of etoposide this patient received was 6,400 mg/m2. Leukemia occurred 11 years after orchiectomy. A literature review revealed 25 other reported cases of secondary leukemias after treatment for testicular carcinoma. It is not clear whether chemotherapy, radiotherapy or both are responsible for the secondary leukemias seen in these patients. Copyright © 1997 S. Karger AG, Basel
- Publication
Urologia Internationalis, 1997, Vol 58, Issue 4, p239
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000282992