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- Title
Combination Chemotherapy in Breast Cancer.
- Authors
Ramirez, Guillermo; Klotz, Jerome; Strawitz, J.G.; Wilson, W.L.; Cornell, G.N.; Madden, R.E.; Minton, J.P.
- Abstract
A randomized clinical trial, involving approximately 100 patients, that compared two combination therapy regimens (5 FU, methotrexate, vincristine, cyclophosphamide with and without prednisone) in advanced breast cancer showed a significantly higher rate of response for the 5-drug therapy group (62.5 versus 44.2 %). However, no significant difference in survival has been observed to date. Some differences in toxicity were observed, e.g. a significantly greater number of cases with mild diarrhea for the 5-drug regimen, and a few more cases of sensory loss (not significant) and significantly more severe leukopenia (p value 0.06) for the 4-drug regimen. Copyright © 1975 S. Karger AG, Basel
- Publication
Oncology, 1975, Vol 32, Issue 3/4, p101
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000225056