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- Title
Method for noninvasive determination of hemoglobin content in biological tissues.
- Authors
Lisenko, S.; Kugeiko, M.
- Abstract
We have developed a simple and efficient method for determining the hemoglobin concentration in biological tissues, based on spatially resolved measurements of the diffuse reflectance of the tissue at λ = 524, 578, and 662 nm (or 773 nm) using multiple regressions between the measured parameters and the hemoglobin concentrations. The method takes into account the presence in the blood of the major hemoglobin derivatives (oxyhemoglobin, deoxyhemoglobin, carboxyhemoglobin, and methemoglobin) and eliminates the effect of the parameters of the top layer of the biological tissue (for example, the epidermis of the skin) and the bulk scattering coefficient of the tissue on the measurement results. Based on numerical Monte Carlo experiments, we have estimated the uncertainties in determining the hemoglobin concentration in skin tissues when its structural and biochemical parameters are all variable.
- Subjects
HEMOGLOBIN derivatives; TISSUES; REGRESSION analysis; MONTE Carlo method; FIBER optics; PROTEIN structure; DEOXYHEMOGLOBIN
- Publication
Journal of Applied Spectroscopy, 2012, Vol 79, Issue 4, p637
- ISSN
0021-9037
- Publication type
Article
- DOI
10.1007/s10812-012-9651-x