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- Title
Tumour suppression: The power of arrest.
- Authors
Heinrichs, Arianne
- Abstract
The article reports on two studies which focus on mouse cancer models that reveal the power of cellular senescence as a p53-mediated mechanism of tumor suppression. Both studies offers the in vivo evidence for the hypothesis that senescence induced by telomere dysfunction is a powerful tumor suppression mechanism. Moreover, the findings of the inquiries imply that the requirements for an apoptotic response or senescence, or both might be context dependent.
- Subjects
TUMORS; CANCER; TELOMERES; CHROMOSOMES; BIOMOLECULES; BIOCHEMICAL genetics; PROTEINS
- Publication
Nature Reviews Molecular Cell Biology, 2007, Vol 8, Issue 7, p514
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm2200