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- Title
Radiation Exposure, the ATM Gene, and Contralateral Breast Cancer in the Women's Environmental Cancer and Radiation Epidemiology Study.
- Authors
Bernstein, Jonine L.; Haile, Robert W.; Stovall, Marilyn; Boice Jr., John D.; Shore, Roy E.; Langholz, Bryan; Thomas, Duncan C.; Bernstein, Leslie; Lynch, Charles F.; Olsen, Jorgen H.; Malone, Kathleen E.; Mellemkjaer, Lene; Borresen-Dale, Anne-Lise; Rosenstein, Barry S.; Teraoka, Sharon N.; Diep, Anh T.; Smith, Susan A.; Capanu, Marinela; Reiner, Anne S.; Xiaolin Liang
- Abstract
Background: Ionizing radiation is a known mutagen and an established breast carcinogen. The ATM gene is a key regulator of cellular responses to the DNA damage induced by ionizing radiation. We investigated whether genetic variants in ATM play a clinically significant role in radiation-induced contralateral breast cancer in women.
- Subjects
CANCER radiotherapy; BREAST cancer; PHYSIOLOGICAL effects of ionizing radiation; DNA damage; CANCER genetics; CANCER in women
- Publication
JNCI: Journal of the National Cancer Institute, 2010, Vol 102, Issue 7, p475
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djq055