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- Title
Different treatment outcomes in schizophrenia - a twin case presentation in bulgaria.
- Authors
Stoimenova-Popova, M.; Stoichev, K.; Chumpalova, P.; Veleva, I.; Tumbev, L.; Todorov, A.; Dimitrova, E.; Krasteva, E.
- Abstract
Introduction: Schizophrenia is a complex psychiatric disorder-its pathogenesis remains unclear, symptomatology as well as treatment outcomes vary among patients. Objectives: To report different treatment outcomes with different treatment approaches between two female monozygotic twins suffering from schizophrenia. Methods: Patients were clinically observed after diagnosis for five years, approximately twice per year. Their functionality level was evaluated based on daily activities. Results: Both twins were diagnosed with paranoid schizophrenia during university (twin A at the age of 23, one year earlier than Twin B). Although twin A experienced a less severe premorbid disorder manifestation than her sister, she was hospitalized and treated with haloperidol, discontinued her education and minimized her social contacts, whereas twin B was treated in an outpatient setting with aripiprazole per os, was stabilized in 3 months' time, continued her studies and had a stable relationship. Twin A had a relapse 13 months after the diagnosis, experienced a second 3-month hospitalization and was discharged with amisulprid 600mg/day, refusing long-acting injectable treatment. After her sister's relapse, twin B decided to start long-acting aripiprazole to reduce the risk of another episode and protect her own functionality. Twin A had 3 more episodes in the following 3 years and is currently on clozapine, 75% disabled and without social contacts. Twin B has successfully graduated university, is married with a 5-month child and is still under long-acting injectable aripiprazole. Conclusions: Different treatment approaches may lead to different treatment outcomes in early onset schizophrenia, evenwhen patients share the same genome and environment.
- Subjects
TREATMENT effectiveness; TWINS; SCHIZOPHRENIA; SOCIAL contact; FETOFETAL transfusion; SOCIAL interaction
- Publication
European Psychiatry, 2020, Vol 63, pS253
- ISSN
0924-9338
- Publication type
Article