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- Title
1882 – The association between post-stroke depression and mortality: a metaanalysis.
- Authors
Bartoli, F.; Lillia, N.; Lax, A.; Crocamo, C.; Mantero, V.; Pini, E.; Carrà, G.; Agostoni, E.; Clerici, M.
- Abstract
Introduction: Stroke represents the third most frequent cause of mortality in developed countries, following only coronary heart diseases and cancer. Post-Stroke Depression (PSD) is extremely common among stroke survivors, and it may have great burden on the likelihood of functional recovery and long-term outcomes. We hypothesized that PSD is related to a higher rate of mortality among people suffering from a stroke. Aim: To estimate the risk of mortality among subjects suffering from PSD as compared with stroke survivors who did not suffer from PSD. Methods: We performed a systematic review of papers indexed in Pubmed. Both fixed and random-effects methods for estimating association and time-to-event pooled effects were used. The presence and the level of heterogeneity were assessed using Q test and I2 statistic. Results: Seven papers had data suitable for meta-analysis. The pooled association effect for mortality at follow-up in people with PSD were statistically significant (p<0.05). The time-to-event estimation showed a statistically significant correlation exclusively under the fixed effect analysis. Conclusions: These findings pointed out the potential burden of PSD on post stroke mortality. Further investigation is required to clarify the nature of PSD/mortality association.
- Subjects
CORONARY disease; STROKE; MORTALITY; MENTAL depression; DEATH
- Publication
European Psychiatry, 2013, Vol 28, p1
- ISSN
0924-9338
- Publication type
Abstract
- DOI
10.1016/S0924-9338(13)76838-X