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- Title
Lymph node ratio predicts local recurrence for periampullary tumours.
- Authors
Lee, Sung Ryol; Kim, Hyung Ook; Park, Yong Lai; Shin, Jun Ho
- Abstract
Background To better define the prognostic role of nodal disease, evaluation of metastatic lymph node ratio ( MLR) has been performed, and this method has recently gained prominence in various gastrointestinal cancers. The present study attempts to identify prognostic factors and evaluate the independent prognostic influence of MLR in patients who have undergone curative pancreaticoduodenectomy. Methods In our institution within the study period, 111 patients received curative pancreaticoduodenectomy for periampullary cancers. Clinicopathologic data were collected and MLR was calculated for each of the patients. Patients were then divided into four groups based on MLR value: MLR 1 = 0; MLR 2 = 0.01-0.2; MLR 3 0.21-0.4; and MLR 4 >0.4. Results Increasing MLR correlates with high recurrence rate and lower overall survival ( OS) with significance ( P < 0.001, P < 0.001). The recurrent group showed significantly lower OS than the non-recurrent group ( P < 0.001). In the multivariate analysis for recurrence, MLR was identified as the only independent prognostic factor ( P < 0.001). Conclusions The simple and easily obtainable MLR is well qualified as a prognostic factor in patients who undergo curatively radical resection for periampullary cancer. Furthermore, MLR can overcome the limitations of evaluation of lymph nodes status, allowing it to be used as a potential prognostic factor.
- Subjects
LYMPH nodes; GASTROINTESTINAL cancer; PANCREATICODUODENECTOMY; MULTIVARIATE analysis; PROGNOSIS
- Publication
ANZ Journal of Surgery, 2014, Vol 84, Issue 5, p353
- ISSN
1445-1433
- Publication type
Article
- DOI
10.1111/ans.12129