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- Title
Safety and Efficacy of a Pharmacist-Managed Patient-Controlled Analgesia Service in Postsurgical Patients.
- Authors
McGonigal, Katrina H.; Giuliano, Christopher A.; Hurren, Jeff
- Abstract
Purpose To compare the safety and efficacy of a pharmacist-managed patient-controlled analgesia ( PCA) service with physician/midlevel provider-managed (standard) PCA services in postsurgical patients. Methods This was a multicenter, retrospective cohort study performed at 3 major hospitals in the Detroit, Michigan, metropolitan area. Postsurgical patients from October 2012 to December 2013 were included. The primary outcome compared the pain area under the curve adjusted for time on PCA ( AUC/T) of patients receiving pharmacist-managed PCA services vs. standard care, up to 72 hours after initiation of PCA. Secondary outcomes included initial opioid selection, programmed PCA settings, duration of PCA use, frequency of adjunct analgesia utilization, and frequency of breakthrough analgesia utilization. Safety outcomes were assessed as a composite safety endpoint and individually. Results Total pain AUC/T scores did not differ between the pharmacist-managed and standard-managed groups (3.25 vs. 3.25, respectively; P = 0.98). Adjunct pain medications were given with similar frequency in the 2 groups; however, significantly fewer patients required breakthrough pain medication in the pharmacist-managed group (11% vs. 36%, respectively; P < 0.0001). A composite endpoint of any adverse event occurring was found to be greater in the pharmacist-managed group. This was driven by a higher proportion of patients requiring antiemetic use (46% vs. 32%; P = 0.04). Conclusion A pharmacist-managed PCA service provided no difference in pain control compared to standard management. The requirement for breakthrough analgesia was decreased in the pharmacist group, while the need for antiemetic use was increased. Further research should be conducted to evaluate different PCA management strategies.
- Subjects
MICHIGAN; THERAPEUTIC use of narcotics; ANALGESICS; ANTIEMETICS; COMPARATIVE studies; LONGITUDINAL method; PATIENT-controlled analgesia; PATIENTS; PATIENT safety; POSTOPERATIVE pain; SURGERY; TREATMENT effectiveness; RETROSPECTIVE studies; MEDICATION therapy management; BREAKTHROUGH pain; THERAPEUTICS
- Publication
Pain Practice, 2017, Vol 17, Issue 7, p859
- ISSN
1530-7085
- Publication type
Article
- DOI
10.1111/papr.12532