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- Title
Alteración en la expresión de proteínas transportadoras de colesterol y moléculas inmunomoduladoras en pacientes con VIH-1.
- Authors
Rubén Darío, Arias-Pérez; Nataly, Arboleda-Álvarez; Catalina, Sánchez-Gómez; Lizdany, Flórez-Alvarez; Damariz, Marín-Palma; Natalia A., Taborda; Juan C., Hernandez
- Abstract
Because antiretroviral therapy fails to control the immune activation that occurs during HIV-1 infection, the study of immunomodulatory molecules may provide alternative strategies for their control. In this sense, the aim of the research was to evaluate the transcriptional expression of molecules associated with the metabolism of high-density lipoproteins and with the inflammatory response mediated by the NLRP3 inflammasome in patients infected with HIV-1. This is a cross-sectional study, which included 23 HIV-1 patients without antiretroviral treatment, with different stages of progression, 7 of which are controllers (Viral load <2000 copies/mL) and 16 progressors (Viral load >2000 copies/mL), in addition to 7 healthy controls. In peripheral blood mononuclear cells, the levels of transcriptional expression of ABCA-1, ABCA-3, Caspase-5 and TXNIP were quantified by RT-PCR. The association of these parameters with laboratory and demographic variables was evaluated and it was found that HIV-1 progressing individuals showed significantly lower levels of TXNIP and ABCA-3, suggesting that during HIV-1 infection there is an alteration in the expression of these molecules. Given the complexity of the immunometabolic interactions during HIV-1 infection, additional studies are needed to establish the precise mechanisms involved in these alterations.
- Publication
Revista Kasmera, 2021, Vol 49, Issue 1, p1
- ISSN
0075-5222
- Publication type
Article
- DOI
10.5281/zenodo.4780969