We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
IgG Antibody Responses Are Preferential Compared With IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection.
- Authors
Longley, Rhea J; White, Michael T; Brewster, Jessica; Liu, Zoe S J; Bourke, Caitlin; Takashima, Eizo; Harbers, Matthias; Tham, Wai-Hong; Healer, Julie; Chitnis, Chetan E; Monteiro, Wuelton; Lacerda, Marcus; Sattabongkot, Jetsumon; Tsuboi, Takafumi; Mueller, Ivo
- Abstract
To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.
- Subjects
THAILAND; BRAZIL; IMMUNOGLOBULIN G; ANTIBODY formation; PLASMODIUM vivax; IMMUNOGLOBULIN M; SENSITIVITY &; specificity (Statistics)
- Publication
Open Forum Infectious Diseases, 2021, Vol 8, Issue 6, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofab228