We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Growth Retardation of Fetal Rats Exposed to Nicotine In Utero: Possible Involvement of CYPIA1, CYP2E1, and P-Glycoprotein.
- Authors
Ting Wang; Man Chen; You-e Yan; Feng-qin Xiao; Xiao-liang Pan; Hui Wang
- Abstract
This article discusses research that aims to determine the effects of prenatal nicotine exposure on fetal development, cytochrome expression, and P-glycoprotein (Pgp) expression in the liver and placenta of the mother. This is intended to examine the metabolic mechanism of intrauterine growth retardation that may be induced by nicotine toxicity. Pregnant rats received nicotine subcutaneously for a given period during gestation. Nicotine-treated rats had low body weights, and maternal liver microsomes increased with progressing gestation before returning to near control levels in late pregnancy. By evaluating gene expression and fetal growth, it was posited that nicotine may contribute to oxidative stress and lipid peroxidation.
- Subjects
NICOTINE; PRENATAL influences; FETAL development; CYTOCHROMES; GLYCOPROTEINS; TOXICITY testing; LABORATORY rats; MICROSOMES
- Publication
Environmental Toxicology, 2009, Vol 24, Issue 1, p33
- ISSN
1520-4081
- Publication type
Article
- DOI
10.1002/tox.20391