We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Netrin as a Novel Biomarker and Its Therapeutic Implications in Diabetes Mellitus and Diabetes-Associated Complications.
- Authors
Yimer, Ebrahim M.; Zewdie, Kaleab Alemayehu; Hishe, Hailemichael Zeru
- Abstract
Diabetes is a multifactorial metabolic syndrome and is one of the shared long-lasting illnesses globally. It is linked to long-term microvascular and macrovascular complications that contribute to disability, compromised quality of life, and reduction in lifespan, which eventually leads to death. This disease is not only incurring significant economic burden but also adversely affects the patients, caregivers, communities, and the society at large. The interruption of diabetes progress and its complications is a primary focus of scientific communities. In spite of various diagnostic modalities for diabetes, there is a limited marker to investigate the risk and progress of its complications. Netrin has recently received more attention as a biomarker of diabetes and a broader range of long-term complication. Therefore, the impetus of this review is to exhaustively discuss the role of Netrin as a potential biomarker and its therapeutic implication in diabetes and diverse sets of microvascular and macrovascular complications of diabetes. It also discourses the possible mechanisms of Netrin for the said pharmacological effect for a better understanding of the development and progression of diabetes and its complications in relation to this protein. It enables protective measures to be applied at the subclinical stage and the responses to preventive or therapeutic measures to be scrutinized. Besides, it might also facilitate the appraisal of novel therapeutic options for diabetes and various complications through modifying the endogenous Netrin and provide surrogate endpoints for intervention.
- Subjects
DIAGNOSIS of diabetes; DIABETES risk factors; TREATMENT of diabetes; CARBOHYDRATE intolerance; ENDOCRINE diseases; BIOLOGICAL tags; GENETICS
- Publication
Journal of Diabetes Research, 2018, p1
- ISSN
2314-6745
- Publication type
Article
- DOI
10.1155/2018/8250521