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- Title
Antimicrobial Effect of Titanium Hydroxyapatite in Denture Base Resin.
- Authors
Sato, Wataru; Yoshida, Yasuo; Komasa, Satoshi; Hasegawa, Yoshiaki; Okazaki, Joji
- Abstract
In the current study, we investigated the antimicrobial effect of titanium hydroxyapatite (TiHA), a photo-oxidizing organic material, in denture base resin on single-species biofilms formed by laboratory bacteria and on multispecies biofilms formed by bacteria from the human saliva. Although TiHA reportedly restricts the growth of planktonic bacteria upon ultraviolet A (UVA) irradiation, the antimicrobial effect of TiHA on bacterial biofilms remains to be elucidated. Resin specimens were prepared by adding TiHA to polymethyl methacrylate-based, denture base resin. The specimens were incubated with biofilm-forming <italic>Streptococcus sanguinis</italic>, <italic>Actinomyces naeslundii</italic>, <italic>Staphylococcus aureus</italic>, <italic>Escherichia coli</italic>, or bacteria from the human saliva obtained from volunteers. After UVA irradiation, the colony-forming units (CFUs) from the biofilms formed on the specimens were determined. CFU numbers for <italic>S. sanguinis</italic>, <italic>A. naeslundii</italic>, and <italic>S. aureus</italic> that formed biofilms on TiHA-containing specimens were significantly lower than those formed on specimens without TiHA. TiHA did not reduce the CFUs of biofilm-forming <italic>E. coli</italic>. In all cases, CFU numbers in the biofilms formed on TiHA-containing specimens by the salivary bacteria were significantly reduced. In addition, neither a 56 h UVA irradiation nor a 28 d soaking in water diminished the antibacterial effect of TiHA. TiHA in denture base resin exerts an antimicrobial effect on single-species bacterial biofilms and biofilms formed by a wide variety of bacteria from human saliva.
- Subjects
TITANIUM hydride; ANTI-infective agents; HYDROXYAPATITE in medicine
- Publication
Applied Sciences (2076-3417), 2018, Vol 8, Issue 6, p963
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app8060963