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- Title
Tunable Degradation Rate and Favorable Bioactivity of Porous Calcium Sulfate Scaffolds by Introducing Nano-Hydroxyapatite.
- Authors
Jianhua Zhou; Fulai Yuan; Shuping Peng; Hui Xie; Ping Wu; Pei Feng; Chengde Gao; Youwen Yang; Wang Guo; Duan Lai; Zhiyang Zhou; Xueling Zhu; Cijun Shuai
- Abstract
The bone scaffolds should possess suitable physicochemical properties and osteogenic activities. In this study, porous calcium sulfate (CaSO4) scaffolds were fabricated successfully via selected laser sintering (SLS). Nano-hydroxyapatite (nHAp), a bioactive material with a low degradation rate, was introduced into CaSO4 scaffolds to overcome the overquick absorption. The results demonstrated that nHAp could not only control the degradation rate of scaffolds by adjusting their content, but also improve the pH environment by alleviating the acidification progress during the degradation of CaSO4 scaffolds. Moreover, the improved scaffolds were covered completely with the apatite spherulites in simulated body fluid (SBF), showing their favorable bioactivity. In addition, the compression strength and fracture toughness were distinctly enhanced, which could be ascribed to large specific area of nHAp and the corresponding stress transfer.
- Subjects
CALCIUM sulfate; HYDROXYAPATITE; LASER sintering
- Publication
Applied Sciences (2076-3417), 2016, Vol 6, Issue 12, p411
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app6120411