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- Title
Relationship between β-cell responsiveness and fasting plasma glucose in Caucasian subjects with newly presenting Type 2 diabetes.
- Authors
Hovorka, R.; Albarrak, A.; Chassin, L.; Luzio, S. D.; Playle, R.; Owens, D. R.
- Abstract
Abstract Aims β-cell responsiveness was related to fasting plasma glucose to gain further understanding of pathophysiology of Type 2 diabetes. Methods An insulin secretion model gave fasting β-cell responsiveness M0 (ability of fasting glucose to stimulate β-cell) and postprandial β-cell responsiveness MI (ability of postprandial glucose to stimulate β-cell) by analysing glucose and C-peptide time-concentration curves sampled every 10–30 min over 240 min during a meal tolerance test (MTT; 75 g CHO, 500 kcal). Caucasian subjects with newly presenting Type 2 diabetes according to WHO criteria (N = 83, male/female: 65 : 18, age: 54 ± 10 years, body mass index (BMI): 30.9 ± 5.2 kg/m2, fasting plasma glucose (FPG): 11.0 ± 3.2 mmol/L; mean ± SD) and Caucasian healthy subjects (N = 54, m/f: 21 : 33, age: 48 ± 9 years, BMI: 26.1 ± 3.7 kg/m2, FPG: 5.1 ± 0.4 mmol/L) were studied. Results A continuum inverse relationship between MI and FPG was observed. In the diabetes group, MI was closely related to FPG (rs = -0.74, P < 0.0001) and explained 60% intersubject FPG variability with the use of an exponential regression model. Conclusions In newly presenting Type 2 diabetes in Caucasian subjects a close inverse association exists between postprandial β-cell responsiveness and FPG. Diabet. Med. 18, 797–802 (2001).
- Subjects
TYPE 2 diabetes; PANCREATIC beta cells; GLUCOSE; C-peptide
- Publication
Diabetic Medicine, 2001, Vol 18, Issue 10, p797
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1046/j.0742-3071.2001.00567.x