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- Title
Kombinační léčba arteriální hypertenze.
- Authors
Novák, Antonín; Ryglová, Jana; Zemanová, Lucie
- Abstract
In the case report, we want to show the treatment of arterial hypertension with a fixed combination of trandalopril / verapamil, which was used in this patient more than 12 years ago, at the time of the onset of fixed dual combinations of ACE inhibitors and calcium blockers. Trandalopril is an established ACE inhibitor, with a long half-life. When initiating treatment in hypertensive patients, we prefer this type of blocker over AT blockers for the advantageous concomitant blockade of bradykinin. Similarly, verapamil has been validated in studies and practice for more than three decades. Above that, it has a specific position in the group of calcium blockers, in addition to the vasodilating effect, it also has a bradycarging effect. It is preferred where the beta-blockers are contraindicated. Both drugs also have a neutral metabolic side effect on glycemia and lipids, in contrast to, for example, diuretics and beta-blockers.
- Publication
Medicina po Promoci, 2020, Vol 21, Issue 3, p247
- ISSN
1212-9445
- Publication type
Article