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- Title
Effect of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity—A PREVIEW randomized clinical trial.
- Authors
Dorenbos, Elke; Drummen, Mathijs; Adam, Tanja; Rijks, Jesse; Winkens, Bjorn; Martínez, J. Alfredo; Navas‐Carretero, Santiago; Stratton, Gareth; Swindell, Nils; Stouthart, Pauline; Mackintosh, Kelly; Mcnarry, Melitta; Tremblay, Angelo; Fogelholm, Mikael; Raben, Anne; Westerterp‐Plantenga, Margriet; Vreugdenhil, Anita
- Abstract
Summary: Background: Pubertal insulin resistance (IR) is associated with increased risk of type 2 diabetes mellitus development in adolescents with overweight/obesity. Objectives: The PREVIEW study was a randomized parallel trial assessing the change in IR, analyzed by Homeostatic Model Assessment of IR (HOMA‐IR), at 2 years after randomization to a high protein vs a moderate protein diet in adolescents with overweight/obesity. It was hypothesized that a high protein/low glycaemic index diet would be superior in reducing IR compared to a medium protein/medium GI diet, in insulin resistant adolescents with overweight or obesity. Methods: Adolescents with overweight/obesity and IR from the Netherlands, United Kingdom and Spain were randomized into a moderate protein/moderate GI (15/55/30En% protein/carbohydrate/fat, GI ≥ 56) or high protein/low GI (25/45/30En% protein/carbohydrate/fat, GI < 50) diet. Anthropometric and cardiometabolic parameters, puberty, dietary intake and physical activity (PA) were measured and effects on HOMA‐IR were analyzed. Results: 126 adolescents were included in this study (13.6 ± 2.2 years, BMI z‐score 3.04 ± 0.66, HOMA‐IR 3.48 ± 2.28, HP n = 68, MP n = 58). At 2 years, changes in protein intake were not significantly different between timepoints or intervention groups and no effects of the intervention on IR were observed. The retention rate was 39%, while no compliance to the diets was observed. Conclusions: The PREVIEW study observed no effect of a high protein/low GI diet on IR in adolescents with overweight/obesity and IR because of lack of feasibility, due to insufficient retention and dietary compliance after 2 years.
- Subjects
CONFIDENCE intervals; GLYCEMIC index; HIGH-protein diet; INSULIN resistance; LOW-carbohydrate diet; CHILDHOOD obesity; RANDOMIZED controlled trials; DATA analysis software; DESCRIPTIVE statistics; ADOLESCENCE
- Publication
Pediatric Obesity, 2021, Vol 16, Issue 1, p1
- ISSN
2047-6302
- Publication type
Article
- DOI
10.1111/ijpo.12702