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- Title
A novel peptide interferes with Mycobacterium tuberculosis virulence and survival.
- Authors
Samuchiwal, Sachin Kumar; Tousif, Sultan; Singh, Dhiraj Kumar; Kumar, Arun; Ghosh, Anamika; Bhalla, Kuhulika; Prakash, Prem; Kumar, Sushil; Trivedi, Ashish Chandra; Bhattacharyya, Maitree; Das, Gobardhan; Ranganathan, Anand
- Abstract
Tuberculosis (TB) is a huge global burden, with new and resistant strains emerging at an alarming rate, necessitating an urgent need for a new class of drug candidates. Here, we report that SL3, a novel 33‐amino acid peptide, causes debilitating effects on mycobacterial morphology. Treatment with SL3 drastically inhibits the growth of Mycobacterium tuberculosis in vitro as well as in a pre‐clinical mouse model for M.tb infection. Microarray analysis of SL3‐expressing strain demonstrates wide‐scale transcriptional disruption in M.tb. We therefore believe that SL3 and similar peptides may herald a new approach towards discovering new molecules for TB therapy.
- Subjects
TUBERCULOSIS treatment; MYCOBACTERIUM tuberculosis; AMINO acids; MYCOBACTERIAL diseases; PEPTIDES
- Publication
FEBS Open Bio, 2014, Vol 4, Issue 1, p735
- ISSN
2211-5463
- Publication type
Article
- DOI
10.1016/j.fob.2014.08.001