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- Title
Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes.
- Authors
Tsukamoto, Ichiro; Inoue, Shinji; Teramura, Takeshi; Takehara, Toshiyuki; Ohtani, Kazuhiro; Akagi, Masao
- Abstract
Abstract: A local tissue-specific renin–angiotensin system (local RAS) has been identified in many organs. However, no report has described the role of a local RAS in the hypertrophic differentiation of chondrocytes. To examine the role of a local RAS in the hypertrophic differentiation, we activated angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor (AT2R) separately in the cell line ATDC5, which involves differentiation from mesenchymal stem cells to hypertrophic chondrocytes. Activation of AT1R suppressed and activation of AT2R enhanced the expression of markers of hypertrophic differentiation, including type X collagen, matrix metalloproteinase 13 and runt-related transcription factor 2.
- Subjects
ANGIOTENSIN receptors; CARTILAGE cells; CELL differentiation; RENIN-angiotensin system; MESENCHYMAL stem cells; CELL lines
- Publication
FEBS Open Bio, 2013, Vol 3, p279
- ISSN
2211-5463
- Publication type
Article
- DOI
10.1016/j.fob.2013.07.001