We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen‐specific IgE production by inhibiting ɛ germline transcription induced by STAT6 activation.
- Authors
Kim, Yoon Hee; Yoshimoto, Miki; Nakayama, Kazuko; Tanino, Sousuke; Fujimura, Yoshinori; Yamada, Koji; Tachibana, Hirofumi
- Abstract
Interleukin (IL)‐4 is a critical stimulator that induces ɛ germline transcripts (ɛGT) for switch recombination to initiate immunoglobulin (Ig) E and is important in allergic disease pathogenesis. We found pentagalloylglucose (PGG) inhibited IL‐4‐induced ɛGT expression. PGG exerted its inhibitory function by suppressing IL‐4‐induced activation of IL‐4Rα, JAK3 and STAT6. Furthermore, tannic acid, a higher galloylated PGG, attenuated ovalbumin‐induced IgE production in vivo by inhibiting IL‐4‐induced ɛGT expression and the IL‐4 signaling pathway. In conclusion, our results suggest that tannic acid may attenuate allergic diseases by suppressing IgE production by inhibiting IL‐4‐induced signaling.
- Subjects
TANNINS; PENTAGALLOYLGLUCOSE; IMMUNOGLOBULIN E; GERM cells; GENETIC transcription; STAT proteins
- Publication
FEBS Open Bio, 2013, Vol 3, Issue 1, p341
- ISSN
2211-5463
- Publication type
Article
- DOI
10.1016/j.fob.2013.07.008