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- Title
Transcription of N- and O-linked mannosyltransferase genes is modulated by the pacC gene in the human dermatophyte Trichophyton rubrum
- Authors
Mendes, Niege S.; Trevisan, Glauce L.; Silva Cruz, Aline H.; Santos, Rodrigo S.; Peres, Nalu T.A.; Martinez-Rossi, Nilce M.; Rossi, Antonio
- Abstract
Abstract: In fungi, ambient pH sensing involves the activation of the Pal/PacC signalling pathway. In the dermatophyte Trichophyton rubrum, pH-dependent secretion of keratinases, which are major virulence determinants, is affected by disruption of the pacC gene. Here, the transcription profiling of the genes coding for N- and O-linked mannosyltransferases, enzymes involved in protein glycosylation, was evaluated in T. rubrum in response to disruption of the pacC gene and growth in keratin, glucose, and glucose plus glycine. We show that transcription of these mannosyltransferase genes is affected by nutrients at acidic pH and by PacC.
- Subjects
GENETIC transcription; MANNOSYLTRANSFERASE; GENES; TRICHOPHYTON; CELLULAR signal transduction; DERMATOPHYTES; GLYCOSYLATION
- Publication
FEBS Open Bio, 2012, Vol 2, p294
- ISSN
2211-5463
- Publication type
Article
- DOI
10.1016/j.fob.2012.09.005