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- Title
Polish mother and child cohort study (REPRO_PL) - Methodology of follow-up of the children.
- Authors
Polańska, Kinga; Hanke, Wojciech; Jurewicz, Joanna; Sobala, Wojciech; Madsen, Christian; Nafstad, Per; Magnus, Per
- Abstract
Background: A prospective cohort study design gives the opportunity for identification, update of different exposures and their verification by biomarker measurements. The aim of The Polish Mother and Child Cohort Study (REPRO_PL) is to evaluate the impact of exposure to different environmental factors during pregnancy and, after birth, on the pregnancy outcome, children's health and neurodevelopment. Materials and Methods: REPRO_PL cohort was established in 2007. From the cohort of1300 mother-child pairs, 300 children are followed-up until they are two years old to asses the exposure, health status and neurodevelopment. Children are examined twice: at one and two years of age by apediatrician and a psychologist/child development specialist. During each visit, detailed questionnaire is conducted with the mothers and supplemented with the information from the medical charts to have appropriate recognition of the child's health and development. Additionally, the current health status of the child is checked and his/her biometry is performed. Aurine sample is collected from each child for the verification of environmental tobacco smoke (ETS) and polycyclic aromatic hydrocarbons (PAH) exposure. Some children have ablood sample collected for the assessment of the lead and cadmium levels. Child's neurodevelopment is assessed based on Bayley Scales for Infant and Toddler Development (Bayley-III). Results and Conclusions: The results of the study will become available within the next few years and will help to determine the impact of the environmental exposures on children's health and neurodevelopment. REPRO_PL cohort is amiddle-sized cohort, very much focused on specific research questions with the potential for future extension and cooperation.
- Subjects
POLAND; ENVIRONMENTAL exposure; CHILDREN'S health; NEURAL development; BIOMARKERS; PREGNANCY complications
- Publication
International Journal of Occupational Medicine & Environmental Health, 2011, Vol 24, Issue 4, p391
- ISSN
1232-1087
- Publication type
Article
- DOI
10.2478/s13382-011-0026-y