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Characterization of Subtypes of BRAF-Mutant Papillary Thyroid Cancer Defined by Their Thyroid Differentiation Score.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2022, v. 107, n. 4, p. 1030, doi. 10.1210/clinem/dgab851
By:
- Boucai, Laura;
- Seshan, Venkatraman;
- Williams, Michelle;
- Knauf, Jeffrey A.;
- Saqcena, Mahesh;
- Ghossein, Ronald A.;
- Fagin, James A.
Publication type:
Article
Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers.
Published in:
Journal of Clinical Investigation, 2013, v. 123, n. 11, p. 4935, doi. 10.1172/JCI69766
By:
- Ricarte-Filho, Julio C.;
- Sheng Li;
- Garcia-Rendueles, Maria E. R.;
- Montero-Conde, Cristina;
- Voza, Francesca;
- Knauf, Jeffrey A.;
- Heguy, Adriana;
- Viale, Agnes;
- Bogdanova, Tetyana;
- Thomas, Geraldine A.;
- Mason, Christopher E.;
- Fagin, James A.
Publication type:
Article
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation.
Published in:
2011
By:
- Chakravarty, Debyani;
- Santos, Elmer;
- Ryder, Mabel;
- Knauf, Jeffrey A.;
- Xiao-Hui Liao;
- West, Brian L.;
- Bollag, Gideon;
- Kolesnick, Richard;
- Tin Htwe Thin;
- Rosen, Neal;
- Zanzonico, Pat;
- Larson, Steven M.;
- Refetoff, Samuel;
- Ghossein, Ronald;
- Fagin, James A.;
- Liao, Xiao-Hui;
- Thin, Tin Htwe
Publication type:
journal article
Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer.
Published in:
2005
By:
- Ciampi, Raffaele;
- Knauf, Jeffrey A.;
- Kerler, Roswitha;
- Gandhi, Manoj;
- Zhu, Zhaowen;
- Nikiforova, Marina N.;
- Rabes, Hartmut M.;
- Fagin, James A.;
- Nikiforov, Yuri E.
Publication type:
journal article
Switch in signaling control of mTORC1 activity after oncoprotein expression in thyroid cancer cell lines.
Published in:
2014
By:
- Malaguarnera, Roberta;
- Chen, Kuen-Yuan;
- Kim, Tae-Yong;
- Dominguez, Jose M;
- Voza, Francesca;
- Ouyang, Bin;
- Vundavalli, Sushil K;
- Knauf, Jeffrey A;
- Fagin, James A
Publication type:
journal article
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
Published in:
2008
By:
- Schweppe, Rebecca E;
- Klopper, Joshua P;
- Korch, Christopher;
- Pugazhenthi, Umarani;
- Benezra, Miriam;
- Knauf, Jeffrey A;
- Fagin, James A;
- Marlow, Laura A;
- Copland, John A;
- Smallridge, Robert C;
- Haugen, Bryan R
Publication type:
journal article
BRAFV600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase kinase inhibition in thyroid cancer cell lines.
Published in:
2008
By:
- Leboeuf, Rebecca;
- Baumgartner, Jacqueline E;
- Benezra, Miriam;
- Malaguarnera, Roberta;
- Solit, David;
- Pratilas, Christine A;
- Rosen, Neal;
- Knauf, Jeffrey A;
- Fagin, James A
Publication type:
journal article
BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Poorly Differentiated Carcinomas Arising from Papillary Carcinomas.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2003, v. 88, n. 11, p. 5399, doi. 10.1210/jc.2003-030838
By:
- NIKIFOROVA, MARINA N.;
- KIMURA, EDNA T.;
- GANDHI, MANOJ;
- BIDDINGER, PAUL W.;
- KNAUF, JEFFREY A.;
- BASOLO, FULVIO;
- ZHU, ZHAOWEN;
- GIANNINI, RICCARDO;
- SALVATORE, GIULIANA;
- FUSCO, ALFREDO;
- SANTORO, MASSIMO;
- FAGIN, JAMES A.;
- NIKIFOROV, YURI E.
Publication type:
Article
Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.
Published in:
2002
By:
- KNAUF, JEFFREY A.;
- WARD, LAURA S.;
- NIKIFOROV, YURI E.;
- NIKIFOROVA, MARINA;
- PUXEDDU, EFISIO;
- MEDVEDOVIC, MARIO;
- LIRON, TAMAR;
- MOCHLY-ROSEN, DARIA;
- FAGIN, JAMES A.
Publication type:
journal article
Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors.
Published in:
Molecular Cancer, 2022, v. 21, n. 1, p. 1, doi. 10.1186/s12943-022-01676-9
By:
- Garcia-Rendueles, Maria E. R.;
- Krishnamoorthy, Gnana;
- Saqcena, Mahesh;
- Acuña-Ruiz, Adrian;
- Revilla, Giovanna;
- de Stanchina, Elisa;
- Knauf, Jeffrey A.;
- Lester, Rona;
- Xu, Bin;
- Ghossein, Ronald A.;
- Fagin, James A.
Publication type:
Article
Acute expression of RET/PTC induces isozyme-specific activation and subsequent downregulation of PKC? in PCCL3 thyroid cells.
Published in:
Oncogene, 2003, v. 22, n. 44, p. 6830, doi. 10.1038/sj.onc.1206829
By:
- Knauf, Jeffrey A;
- Ouyang, Bin;
- Croyle, Mickey;
- Kimura, Edna;
- Fagin, James A
Publication type:
Article
RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase.
Published in:
Oncogene, 2003, v. 22, n. 28, p. 4406, doi. 10.1038/sj.onc.1206602
By:
- Knauf, Jeffrey A;
- Kuroda, Hiroaki;
- Basu, Saswata;
- Fagin, James A
Publication type:
Article
91st American Thyroid Association Annual Meeting Preview: Live and in Person in Montréal! October 19–23, 2022 Montréal, Quebec, Canada.
Published in:
2022
By:
- Papaleontiou, Maria;
- McCabe, Christopher J.;
- Angell, Trevor E.;
- Brent, Gregory A.;
- Cano, Raquel;
- Duntas, Leonidas;
- Fox, Larry;
- Goldfarb, Melanie;
- Goldner, Whitney;
- Kitahara, Cari M.;
- Knauf, Jeffrey A.;
- Mariash, Cary;
- Miragaya, Joanna;
- Neumann, Susanne;
- Nikiforova, Marina;
- Patel, Kepal;
- Rangel, Leonardo;
- Shah, Manisha H.;
- Shi, Yun-Bo;
- Stan, Marius N.
Publication type:
Proceeding
Enhancing Radioiodine Incorporation in BRAF-Mutant, Radioiodine-Refractory Thyroid Cancers with Vemurafenib and the Anti-ErbB3 Monoclonal Antibody CDX-3379: Results of a Pilot Clinical Trial.
Published in:
Thyroid, 2022, v. 32, n. 3, p. 273, doi. 10.1089/thy.2021.0565
By:
- Tchekmedyian, Vatche;
- Dunn, Lara;
- Sherman, Eric;
- Baxi, Shrujal S.;
- Grewal, Ravinder K.;
- Larson, Steven M.;
- Pentlow, Keith S.;
- Haque, Sofia;
- Tuttle, R. Michael;
- Sabra, Mona M.;
- Fish, Stephanie;
- Boucai, Laura;
- Walters, Jamie;
- Ghossein, Ronald A.;
- Seshan, Venkatraman E.;
- Knauf, Jeffrey A.;
- Pfister, David G.;
- Fagin, James A.;
- Ho, Alan L.
Publication type:
Article
Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness.
Published in:
Thyroid, 2019, v. 29, n. 1, p. 79, doi. 10.1089/thy.2018.0424
By:
- Boufraqech, Myriem;
- Patel, Dhaval;
- Nilubol, Naris;
- Powers, Astin;
- King, Timothy;
- Shell, Jasmine;
- Lack, Justin;
- Zhang, Lisa;
- Gara, Sudheer Kumar;
- Gunda, Viswanath;
- Klubo-Gwiezdzinska, Joanna;
- Kumar, Suresh;
- Fagin, James;
- Knauf, Jeffrey;
- Parangi, Sareh;
- Venzon, David;
- Quezado, Martha;
- Kebebew, Electron
Publication type:
Article
BRAF V600E Expression in Thyrocytes Causes Recruitment of Immunosuppressive STABILIN-1 Macrophages.
Published in:
Cancers, 2022, v. 14, n. 19, p. 4687, doi. 10.3390/cancers14194687
By:
- Spourquet, Catherine;
- Delcorte, Ophélie;
- Lemoine, Pascale;
- Dauguet, Nicolas;
- Loriot, Axelle;
- Achouri, Younes;
- Hollmén, Maija;
- Jalkanen, Sirpa;
- Huaux, François;
- Lucas, Sophie;
- Meerkeeck, Pierre Van;
- Knauf, Jeffrey A.;
- Fagin, James A.;
- Dessy, Chantal;
- Mourad, Michel;
- Henriet, Patrick;
- Tyteca, Donatienne;
- Marbaix, Etienne;
- Pierreux, Christophe E.
Publication type:
Article
The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway.
Published in:
Oncogene, 2000, v. 19, n. 34, p. 3948, doi. 10.1038/sj.onc.1203723
By:
- Saavedra, Harold I;
- Knauf, Jeffrey A;
- Shirokawa, Jill M;
- Wang, Jianwei;
- Ouyang, Bin;
- Elisei, Rosella;
- Stambrook, Peter J;
- Fagin, James A
Publication type:
Article
Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets.
Published in:
Nucleic Acids Research, 1997, v. 25, n. 19, p. 3823, doi. 10.1093/nar/25.19.3823
By:
- Gonsky, Rivkah;
- Knauf, Jeffrey A.;
- Elisei, Rosella;
- Jian Wei Wang;
- Susan Su;
- Fagin, James A.
Publication type:
Article
Hgf/Met activation mediates resistance to BRAF inhibition in murine anaplastic thyroid cancers.
Published in:
2018
By:
- Knauf, Jeffrey A.;
- Luckett, Kathleen A.;
- Kuen-Yuan Chen;
- Voza, Francesca;
- Socci, Nicholas D.;
- Ghossein, Ronald;
- Fagin, James A.;
- Chen, Kuen-Yuan
Publication type:
journal article
Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine.
Published in:
2016
By:
- Nagarajah, James;
- Mina Le;
- Knauf, Jeffrey A.;
- Ferrandino, Giuseppe;
- Montero-Conde, Cristina;
- Pillarsetty, Nagavarakishore;
- Bolaender, Alexander;
- Irwin, Christopher;
- Krishnamoorthy, Gnana Prakasam;
- Saqcena, Mahesh;
- Larson, Steven M.;
- Ho, Alan L.;
- Seshan, Venkatraman;
- Nobuya Ishii;
- Carrasco, Nancy;
- Rosen, Neal;
- Weber, Wolfgang A.;
- Fagin, James A.;
- Le, Mina;
- Ishii, Nobuya
Publication type:
journal article
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.
Published in:
2016
By:
- Landa, Iñigo;
- Ibrahimpasic, Tihana;
- Boucai, Laura;
- Sinha, Rileen;
- Knauf, Jeffrey A.;
- Shah, Ronak H.;
- Dogan, Snjezana;
- Ricarte-Filho, Julio C.;
- Krishnamoorthy, Gnana P.;
- Bin Xu;
- Schultz, Nikolaus;
- Berger, Michael F.;
- Sander, Chris;
- Taylor, Barry S.;
- Ghossein, Ronald;
- Ganly, Ian;
- Fagin, James A.;
- Xu, Bin
Publication type:
journal article
Association of Treatment Strategies and Tumor Characteristics With Overall Survival Among Patients With Anaplastic Thyroid Cancer: A Single-Institution 21-Year Experience.
Published in:
JAMA Otolaryngology-Head & Neck Surgery, 2023, v. 149, n. 4, p. 300, doi. 10.1001/jamaoto.2022.5045
By:
- Wu, Shannon S.;
- Lamarre, Eric D.;
- Yalamanchali, Anirudh;
- Brauer, Philip R.;
- Hong, Hanna;
- Reddy, Chandana A.;
- Yilmaz, Emrullah;
- Woody, Neil;
- Ku, Jamie A.;
- Prendes, Brandon;
- Burkey, Brian;
- Nasr, Christian;
- Skugor, Mario;
- Heiden, Katherine;
- Chute, Deborah J.;
- Knauf, Jeffrey A.;
- Campbell, Shauna R.;
- Koyfman, Shlomo A.;
- Geiger, Jessica L.;
- Scharpf, Joseph
Publication type:
Article
Mouse Models as a Tool for Understanding Progression in Braf<sup>V600E</sup>-Driven Thyroid Cancers.
Published in:
Endocrinology & Metabolism, 2019, v. 34, n. 1, p. 11, doi. 10.3803/EnM.2019.34.1.11
By:
- Landa, Iñigo;
- Knauf, Jeffrey A.
Publication type:
Article
Outcome and molecular characteristics of non-invasive encapsulated follicular variant of papillary thyroid carcinoma with oncocytic features.
Published in:
Endocrine (1355008X), 2019, v. 64, n. 1, p. 97, doi. 10.1007/s12020-019-01848-6
By:
- Xu, Bin;
- Reznik, Ed;
- Tuttle, R. Michael;
- Knauf, Jeffrey;
- Fagin, James A.;
- Katabi, Nora;
- Dogan, Snjezana;
- Aleynick, Nathaniel;
- Seshan, Venkatraman;
- Middha, Sumit;
- Enepekides, Danny;
- Casadei, Gian Piero;
- Solaroli, Erica;
- Tallini, Giovanni;
- Ghossein, Ronald;
- Ganly, Ian
Publication type:
Article
BRAF V600E Induction in Thyrocytes Triggers Important Changes in the miRNAs Content and the Populations of Extracellular Vesicles Released in Thyroid Tumor Microenvironment.
Published in:
Biomedicines, 2022, v. 10, n. 4, p. 755, doi. 10.3390/biomedicines10040755
By:
- Delcorte, Ophélie;
- Spourquet, Catherine;
- Lemoine, Pascale;
- Degosserie, Jonathan;
- Van Der Smissen, Patrick;
- Dauguet, Nicolas;
- Loriot, Axelle;
- Knauf, Jeffrey A.;
- Gatto, Laurent;
- Marbaix, Etienne;
- Fagin, James A.;
- Pierreux, Christophe E.
Publication type:
Article
Does the Epidermal Growth Factor Receptor Play a Role in the Progression of Thyroid Cancer?
Published in:
Thyroid, 2011, v. 21, n. 11, p. 1171, doi. 10.1089/thy.2011.2111.ed
By:
- Knauf, Jeffrey A.
Publication type:
Article
Molecular, Morphologic, and Outcome Analysis of Thyroid Carcinomas According to Degree of Extrathyroid Extension.
Published in:
Thyroid, 2010, v. 20, n. 10, p. 1085, doi. 10.1089/thy.2010.0174
By:
- Michael Rivera;
- Julio Ricarte-Filho;
- Robert Michael Tuttle;
- Ian Ganly;
- Ashok Shaha;
- Jeffrey Knauf;
- James Fagin;
- Ronald Ghossein
Publication type:
Article
Genomic and Transcriptomic Characterization of Papillary Microcarcinomas With Lateral Neck Lymph Node Metastases.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2019, v. 104, n. 10, p. 4889, doi. 10.1210/jc.2019-00431
By:
- Perera, Dilmi;
- Ghossein, Ronald;
- Camacho, Niedzica;
- Senbabaoglu, Yasin;
- Seshan, Venkatraman;
- Juan Li;
- Bouvier, Nancy;
- Boucai, Laura;
- Viale, Agnes;
- Socci, Nicholas D.;
- Untch, Brian R.;
- Gonen, Mithat;
- Knauf, Jeffrey;
- Fagin, James A.;
- Berger, Michael;
- Tuttle, R. Michael
Publication type:
Article
Genomic and Transcriptomic Characterization of Papillary Microcarcinomas With Lateral Neck Lymph Node Metastases.
Published in:
2019
By:
- Perera, Dilmi;
- Ghossein, Ronald;
- Camacho, Niedzica;
- Senbabaoglu, Yasin;
- Seshan, Venkatraman;
- Li, Juan;
- Bouvier, Nancy;
- Boucai, Laura;
- Viale, Agnes;
- Socci, Nicholas D;
- Untch, Brian R;
- Gonen, Mithat;
- Knauf, Jeffrey;
- Fagin, James A;
- Berger, Michael;
- Tuttle, R Michael
Publication type:
journal article
Vemurafenib Redifferentiation of BRAF Mutant, RAI-Refractory Thyroid Cancers.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2019, v. 104, n. 5, p. 1417, doi. 10.1210/jc.2018-01478
By:
- Dunn, Lara A.;
- Sherman, Eric J.;
- Baxi, Shrujal S.;
- Tchekmedyian, Vatche;
- Grewal, Ravinder K.;
- Larson, Steven M.;
- Pentlow, Keith S.;
- Haque, Sofia;
- Tuttle, R. Michael;
- Sabra, Mona M.;
- Fish, Stephanie;
- Boucai, Laura;
- Walters, Jamie;
- Ghossein, Ronald A.;
- Seshan, Venkatraman E.;
- Ai Ni;
- Duan Li;
- Knauf, Jeffrey A.;
- Pfister, David G.;
- Fagin, James A.
Publication type:
Article
Vemurafenib Redifferentiation of BRAF Mutant, RAI-Refractory Thyroid Cancers.
Published in:
2018
By:
- Dunn, Lara A;
- Sherman, Eric J;
- Baxi, Shrujal S;
- Tchekmedyian, Vatche;
- Grewal, Ravinder K;
- Larson, Steven M;
- Pentlow, Keith S;
- Haque, Sofia;
- Tuttle, R Michael;
- Sabra, Mona M;
- Fish, Stephanie;
- Boucai, Laura;
- Walters, Jamie;
- Ghossein, Ronald A;
- Seshan, Venkatraman E;
- Ni, Ai;
- Li, Duan;
- Knauf, Jeffrey A;
- Pfister, David G;
- Fagin, James A
Publication type:
journal article
Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1.
Published in:
Clinical Endocrinology, 2002, v. 56, n. 3, p. 341, doi. 10.1046/j.1365-2265.2002.01475.x
By:
- Ouyang, Bin;
- Knauf, Jeffrey A;
- Ain, Kenneth;
- Nacev, Benjamin;
- Fagin, James A
Publication type:
Article

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