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- Title
The prognostic value of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography in patients with suspected residual or recurrent medullary thyroid carcinoma.
- Authors
Bogsrud, Trond Velde; Karantanis, Dimitrios; Nathan, Mark A.; Mullan, Brian P.; Wiseman, Gregory A.; Kasperbauer, Jan L.; Reading, Carl C.; Björo, Trine; Hay, Ian D.; Lowe, Val J.; Björo, Trine
- Abstract
<bold>Purpose: </bold>To explore the prognostic value of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET) in patients with suspected residual or recurrent medullary thyroid carcinoma (MTC).<bold>Procedures: </bold>This retrospective study included all patients with MTC examined with FDG-PET at Mayo Clinic, Rochester, Minnesota, from October 1999 to March 2008. The PET results were compared with other imaging studies and clinical findings, including carcinoembryonic antigen and calcitonin levels.<bold>Results: </bold>Twenty-nine patients with MTC were included. PET was positive in 14 patients, with follow-up information for 11; six died from metastatic disease, four had disease progression, and one remained in stable condition. PET was negative in 15 patients, with follow-up for 12; one had recurrent disease, and 11 had no evidence of clinical disease. Calcitonin doubling time was shorter for PET-positive than for PET-negative patients.<bold>Conclusion: </bold>FDG-PET has high prognostic value in patients with suspected residual or recurrent MTC.
- Subjects
MINNESOTA; CANCER patients; THYROID cancer; PROGNOSTIC tests; POSITRON emission tomography; CALCITONIN; CANCER cells; DEOXY sugars; LONGITUDINAL method; PROGNOSIS; RADIONUCLIDE imaging; RADIOPHARMACEUTICALS; THYROID gland tumors; DISEASE relapse
- Publication
Molecular Imaging & Biology, 2010, Vol 12, Issue 5, p547
- ISSN
1536-1632
- Publication type
journal article
- DOI
10.1007/s11307-009-0276-2