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- Title
Secretion of cortisol and aldosterone as a vulnerable target for adrenal endocrine disruption—screening of 30 selected chemicals in the human H295R cell model.
- Authors
Ullerås, Erik; Ohlsson, Åsa; Oskarsson, Agneta
- Abstract
The article discusses the study which examines adrenal gland as a primary target for endocrine toxicants. It uses the human adenocortical cell line H295R to screen for effects on sex hormones, cortisol and aldosterone. It explores 30 potential endocrine disrupting chemicals on the secretion of cortisol and aldosterone from the H295R cells using the enzyme-linked immunosorbent assay (ELISA). These chemicals include prochloraz, ketoconazole, and imazalil. The study shows that adrenal steriodogenesis is a vulnerable target for toxic insult and the H295R assay is a useful in vitro model for screening purposes.
- Subjects
ENDOCRINE toxicology; ADRENAL glands; HYDROCORTISONE; ALDOSTERONE; SEX hormones; POISONS; KETOCONAZOLE; ETOMIDATE; ENZYME-linked immunosorbent assay
- Publication
Journal of Applied Toxicology, 2008, Vol 28, Issue 8, p1045
- ISSN
0260-437X
- Publication type
Article
- DOI
10.1002/jat.1371