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- Title
Evaluating the effectiveness of antibiotics in the treatment of aseptic meningitis caused by the MMR vaccine.
- Authors
Mousavipour, Mahshin; Khosravi, Shaqayeq; Dezfouli, Seyedeh Mahsa Mahmoudinezhad; vafajoo, Ahmad; Delavar, Motahare Aghajani; Javid, Asma; Nasersaeid, Mitra; hemmati, Sahar
- Abstract
Introduction: In some cases, MMR vaccine injection causes fever, seizures, parotitis, and aseptic meningitis in children. Since in patients suspected of having meningitis, antibiotics are initially started with a meningeal dose and considering that a group of patients receive antibiotics despite the diagnosis of aseptic meningitis, evaluation of the effectiveness of antibiotics in the treatment of aseptic meningitis caused by the MMR vaccine is necessary in order to prevent drug resistance, indiscriminate use of antibiotics, and additional costs. Materials and methods: In this descriptive-analytical study, which was conducted from 2016 to 2019 at Hazrat Ali Asghar Hospital in Iran, the number of samples studied was 50 patients. The patients were included in the study after checking the children's vaccination cards and considering the inclusion and exclusion criteria. Cerebrospinal fluid samples were taken and sent to the laboratory for culture and analysis and latex agglutination test. Also, in order to ensure the viral origin of the studied meningitis patients, antibiotic effectiveness was evaluated using the disk diffusion method. The demographic and medical information of the patients was recorded in a researcher-made questionnaire, and finally, the data were analyzed using SPSS version 22 software. Results: The mean and standard deviation of the children's age was 13.35±1.26 months. Also, 36.6% of the children were girls and 63.1% of them were boys. The youngest age was 1.2 and the oldest age was 2 years. Among the studied patients, 12 children did not receive antibiotics during hospitalization and 38 people received antibiotics during hospitalization. At first, ceftriaxone was started for 38 people and vancomycin for 36 people. Then, ceftriaxone was continued for 14 people, ceftriaxone and vancomycin for 6 people, cefotaxime for 14 people, and cefotaxime and vancomycin were continued for 4 people. Among the 12 children who did not receive secondary treatment with antibiotics, 10 children had initially received ceftriaxone and 8 children had received vancomycin. Examining the relationship between hospital symptoms and antibiotic prescription showed that the degree of fever was significantly different in both groups. There was no significant relationship between the duration of fever and the use of antibiotics, and also between the duration of hospitalization and the use of antibiotics. Discussion and conclusion: Antibiotic use in children with aseptic meningitis caused by MMR vaccine injection, in addition to having no effect on the treatment, may cause the exacerbation of meningitis complications. Also, there was no significant difference between the duration of hospitalization in people who received antibiotics and patients who did not receive antibiotics.
- Subjects
IRAN; MMR vaccines; MENINGITIS; VACCINATION of children; MILK contamination; AGGLUTINATION tests; CEFTRIAXONE; CEREBROSPINAL fluid
- Publication
Journal of Pharmaceutical Negative Results, 2023, Vol 14, Issue 3, p638
- ISSN
0976-9234
- Publication type
Article
- DOI
10.47750/pnr.2023.14.03.081