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- Title
A placental diploid cell line is not essential for ongoing trisomy 13 or 18 pregnancies.
- Authors
Schuring-Blom, G Heleen; Boer, Kees; Leschot, Nico J
- Abstract
Viable trisomy 13 or 18 pregnancies may be supported by the presence of a diploid cell line, confined to the outer layer of the placenta (cytotrophoblast). To establish the presence of diploid cells we investigated five random biopsies from placentas of trisomy 13 (n=8) and trisomy 18 cases (n=6) of newborn infants and terminated pregnancies by means of fluorescence in situ hybridisation on interphase nuclei (n=100). In 12 of these 14 placentas (including all five liveborns) 80% or more of the analysed nuclei showed three spots, suggestive of the presence of a full trisomy. In the other two placentas (both cases of trisomy 18) mosaicism was detected at most investigated sites. Thus, in contrast with earlier studies, these results show that a significant diploid cell line present in the placenta, confined to the trophoblast, is not a pre-requisite for intrauterine survival in the investigated cases.
- Subjects
TRISOMY; PLACENTA; PREGNANCY; FLUORESCENCE in situ hybridization
- Publication
European Journal of Human Genetics, 2001, Vol 9, Issue 4, p286
- ISSN
1018-4813
- Publication type
Article
- DOI
10.1038/sj.ejhg.5200631