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- Title
Factores de pronóstico de mortalidad en pacientes con síndrome de anticuerpos antifosfolipídicos en una cohorte de pacientes cubanos.
- Authors
Pérez de Alejo-Rodríguez, Marta María; Hernández-Negrín, Halbert; Eduardo Barreto-Fui, Eligio; José Jiménez-Domínguez, Lázaro
- Abstract
OBJECTIVES: To determine the mortality prognostic factors in patients with antiphospholipid syndrome and to compare their survival according to the identified prognostic factors. MATERIALS AND METHODS: Observational analytical case-control study carried out in patients diagnosed with antiphospholipid syndrome treated at the Autoimmune Diseases clinic of the Arnaldo Milián Castro Hospital, Villa Clara, Cuba, from January 1990 to January 2015. They formed two groups: one with deceased patients and the other with living patients. RESULTS: Twenty patients were included in the group of deceased and 80 in the group of living patients. Multivariate analysis identified renal damage (p: 0.001; OR: 16.51; CI: 1.27-23.38), neurological damage (p: 0.030; OR: 5.24; CI: 1.27-23.38), pulmonary embolism (p: 0.033; OR: 9.76; CI: 1.20-79.28), false positivity for VDRL serology (p: 0.025; OR: 8.63; CI: 1.30 -57.14) and arterial thrombosis (p: 0.036; OR: 5.49; CI: 1.11-27.11).With the exception of arterial thromboses, the other factors determined a significantly lower mean survival in the patients who manifested them. CONCLUSIONS: The early identification of these prognostic factors can facilitate the prediction of the outcome of this disease, which represents a decisive tool to prevent fatal complications and decide the most appropriate therapeutic approach, thus contributing to the improvement of the comprehensive care of patients with antiphospholipid syndrome.
- Publication
Medicina Interna de Mexico, 2023, Vol 39, Issue 2, p251
- ISSN
0186-4866
- Publication type
Article
- DOI
10.24245/mim.v39i2.7590