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- Title
Prolif erative Responses to PHA, Anti-CD3 and Antigens in Patients with Lymphoproliferative Disease of Granular Lymphocytes.
- Authors
Giovannetti, Antonello; Quinti, Isabella; Rainaldi, Luana; Maur, Francesca R.; Oliva, Alessandra; Pierdominici, Marina; Ricci, Giovanni; Rossi, Giulio De; Cassone, Antonio; Aiuti, Fernando; Pandolfi, Franco
- Abstract
In this paper we investigated the lymphoproliferative and cytotoxic responses of peripheral blood mononuclear cells (PBMC) of patients affected with lymphoproliferative disease of granular lymphocytes of T cell origin to mitogens and antigens. Most patients with lymphoproliferative disease of granular lymphocytes (LDGL) showed a severely impaired PBMC proliferative capacity in response to phytohemagglutinin, anti-CD3 and tetanus toxoid, an impairment that, in the case of anti-CD 3 response, appears to be related to a defect of phosphorylation in response to triggering. In contrast, at least 50% of the patients had normal proliferation in response to a mannoprotein fraction purified from Candida albicans. These data suggest that some CD3+ GL from LDGL patients, that usually respond poorly to proliferative stimuli in vitro, can be triggered to perform these functions by candidal antigens. Copyright © 1997 S. Karger AG, Basel
- Publication
Acta Haematologica, 1997, Vol 98, Issue 2, p65
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000203594