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- Title
Evaluation of NovoSorb novel biodegradable polymer for the generation of a dermal matrix.
- Authors
Greenwood, J. E.; Li, A.; Dearman, B. L.; Moore, T. G.
- Abstract
Dermal skin substitutes can be used to overcome the immediate problem of donor site shortage in the treatment of major skin loss conditions such as burn injury. In this study the biocompatibility, safety and potential of three variants of NovoSorb™ (a family of novel biodegradable polyurethanes) as dermal scaffolds were determined in-vitro. All three polymers exhibited minimal cytotoxic effects on skin cells allowing human keratinocytes, dermal fibroblasts and microvascular endothelial cells to grow normally in co-culture. Assessment of a three-dimensional polymer matrix followed. A rudimentary composite skin was created with the sequential culturing of dermal fibroblasts and keratinocytes within the matrix. Furthermore, the polymeric matrix provided a scaffold for the guided formation of a cultured microvasculature. These results prompt further investigation in-vivo to assess their safety in biological systems and to elucidate their interaction with the wound environment.
- Subjects
POLYURETHANES; POLYMERS; SKIN injuries; BURNS &; scalds; EPIDERMIS; WOUNDS &; injuries
- Publication
Wound Practice & Research, 2010, Vol 18, Issue 1, p14
- ISSN
1837-6304
- Publication type
Article