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- Title
HPV vaccination impact on a cervical cancer screening program: methods of the FASTER-Tlalpan Study in Mexico.
- Authors
Salmerón, Jorge; Torres-Ibarra, Leticia; Bosch, F. Xavier; Cuzick, Jack; Lörincz, Attila; Wheeler, Cosette M.; Castle, Philip E.; Robles, Claudia; Lazcano-Ponce, Eduardo
- Abstract
Objective. To outline the design of a clinical trial to evaluate the impact of HPV vaccination as part of a hrHPV-based primary screening program to extend screening intervals. Materials and methods. A total of 18,000 women aged 25-45 years, attending the regular cervical cancer-screening program in primary health care services in Tlalpan, Mexico City, will be invited to the study. Eligible participants will be assigned to one of three comparison groups: 1) HPV16/18 vaccine and hrHPV-based screening; 2) HPV6/11/16/18 vaccine and hrHPV-based screening; 3) Control group who will receive only hrHPV-based screening. Strict surveillance of hrHPV persistent infection and occurrence of precancerous lesions will be conducted to estimate safety profiles at different screening intervals; participants will undergo diagnosis confirmation and treatment as necessary. Conclusion. The FASTER-Tlalpan Study will provide insights into new approaches of cervical cancer prevention programs. It will offer valuable information on potential benefits of combinHPVing HPV vaccination and hrHPV-based screening to safety extend screening intervals.
- Subjects
TLALPAN (Mexico); CERVICAL cancer diagnosis; HUMAN papillomavirus vaccines; EARLY detection of cancer; HEALTH programs; CLINICAL trials
- Publication
Salud Pública de México, 2016, Vol 58, Issue 2, p211
- ISSN
0036-3634
- Publication type
Article