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- Title
Antioxidant effects of compound walnut oil capsule in mice aging model induced by D-galactose.
- Authors
Huandong Zhao; Yuxiang Chen; Jian Li; Yang Chen; Juan Zhao; Caiping Ren
- Abstract
Background: Many plant original foods have been shown beneficial effects in humans. In the previous work, we have developed a compound capsule which contains major constituents of walnut oil and grape seed extract. Objective: To investigate the antioxidant effects of the Compound Walnut Oil Capsule (WOC) in aging model induced by D-gal. Design: 70 C57BL/6J mice were randomly divided into seven groups. Mice in normal group received daily subcutaneous injection of saline while the control group, WOC groups, Vitamin C (VC) group and pure walnut oil group received daily subcutaneous injection of D-galactose (D-gal) for 8 weeks. Total antioxidant capacity (T-AOC), super dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) in serum, liver and brain were determined. The expression of Heme Oxygenase (HO-1), iNOS and Klotho in liver and brain were obtained. Results: WOC could improve the pathologic lesions caused by oxidative stress and significantly enhance the T-AOC, increase the activities of SOD, GSH-Px and decrease the contents of MDA in serum, liver and brain. Also, the WOC could obviously up-regulate the expression of HO-1 and Klotho and down-regulate the expression of iNOS. Conclusion: WOC can be used as an anti-aging food for its effectively eliminating free radicals, enhancing the antioxidant capacity and alleviating the damages of oxidative stress.
- Subjects
SUBCUTANEOUS injections; AGING; ANIMAL experimentation; BRAIN; PHARMACEUTICAL encapsulation; GENE expression; LIVER; MICE; OXIDOREDUCTASES; PHYSIOLOGIC salines; STATISTICAL sampling; SUPEROXIDE dismutase; VEGETABLE oils; VITAMIN C; WALNUT; MALONDIALDEHYDE; OXIDATIVE stress; HEXOSES
- Publication
Food & Nutrition Research, 2018, Vol 62, p1
- ISSN
1654-6628
- Publication type
Article
- DOI
10.29219/fnr.v62.1371