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- Title
Anti-inflammatory Benzofurans from the Heartwood of Dalbergia cochinchinensis Pierre ex Laness.
- Authors
Qiwan Zheng; Canyue Ouyang; Yang Liu; Jiahui Ren; Xianwen Wei; Ronghua Liu; Lanying Chen
- Abstract
A new benzofuran, Cochinfuran A (1), and four known benzofurans (2-5) were isolated from the heartwood of Dalbergia cochinchinensis Pierre ex Laness. The chemical structure of the new benzofuran was determined based on broad NMR and mass spectrometry evaluation. Bioactivity assays showed that the compounds 1-3 and 5 were found as anti-inflammatory agents with IC50 values 49.01 ± 1.54, 1368.93 ± 0.98, 67.48 ± 0.92 and 77.91 ± 1.53 µM, respectively. They could reduce the production of NO (P<0.001) with 3.52~7.04, 1.96~7.84, 1.85~7.40 and 0.98~3.93 µM and restrained LDH (P<0.01) with 3.52~7.04, 3.93~7.84, 3.70~7.40 and 0.98~3.93 µM in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, respectively, the compound 4 (IC50 218.20 ± 3.39 µM) showed no anti-inflammatory activity.
- Subjects
HEARTWOOD; MASS spectrometry; CHEMICAL structure; ANTI-inflammatory agents; BENZOFURAN
- Publication
Records of Natural Products, 2023, Vol 17, Issue 3, p549
- ISSN
1307-6167
- Publication type
Article
- DOI
10.25135/rnp.371.2210.2594