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- Title
Relationship between diastolic blood pressure and the first ischaemic stroke in elderly patients with hypertension.
- Authors
Chao-Lei Chen; Jia-Yi Huang; Lin Liu; Yu-Ling Yu; Geng Shen; Kenneth Lo; Yu-Qing Huang; Song-tao Tang; Ying Qing Feng; Chen, Chao-Lei; Huang, Jia-Yi; Liu, Lin; Yu, Yu-Ling; Shen, Geng; Lo, Kenneth; Huang, Yu-Qing; Tang, Song-Tao; Feng, Ying Qing
- Abstract
<bold>Background: </bold>It is uncertain how diastolic blood pressure (DBP) may associate with ischaemic stroke in elder patients with hypertension. We aimed to explore this relationship in a Chinese community.<bold>Methods: </bold>A total of 3315 participants aged ≥60 years with essential hypertension were enrolled between January 2010 and December 2011, and being followed up until 31 December 2016. DBP levels were categorised into five groups (<60, 60-70, 70-80, 80-90 and ≥90 mm Hg), using 70-80 mm Hg as referent. We performed Cox regression analysis and subgroup analyses to evaluate the relationship between DBP and the incidence of ischaemic stroke.<bold>Results: </bold>Among the 3315 participants, 44.49% were men and they were 71.4 years old on average. During a median follow-up period of 5.5 years, there were 206 onset cases of ischaemic stroke. The HRs for the first ischaemic stroke in the fully adjusted model were 1.32 (95% CI 0.73 to 2.40) for DBP <70 mm Hg, 1.50 (95% CI 1.13 to 2.73) for DBP between 80 and 89.9 mm Hg and 2.31 (95% CI 1.14 to 4.68) for DBP ≥90 mm Hg compared with DBP between 70 and 79.9 mm Hg (p=0.020 for trend). Subgroup and interaction analysis showed no significant findings.<bold>Conclusions: </bold>DBP had a non-linear association with the risk of ischaemic stroke among Chinese elderly patients with hypertension. DBP between 70 and 80 mm Hg may be an appropriate indicator for a lower stroke risk.
- Subjects
BLOOD pressure; OLDER patients; LACUNAR stroke; STROKE patients; DYSLIPIDEMIA
- Publication
Postgraduate Medical Journal, 2020, Vol 96, Issue 1139, p525
- ISSN
0032-5473
- Publication type
journal article
- DOI
10.1136/postgradmedj-2019-137018